Carlos Bustamante

Professor of Chemistry, Physics and Molecular and Cell Biology; The Raymond and Beverly Sackler Professor in Biophysics; Howard Hughes Medical Institute Investigator

Our laboratory develops and applies single-molecule manipulation methods, such as optical and magnetic tweezers, to characterize the dynamics and the mechanochemical properties of various molecular motors, such as RNA polymerase II, the ribosome, the ClpXP protease, the φ29 DNA packaging motor, and SpoIIIE – a molecular motor involved in bacterial sporulation.  We also use and develops novel methods for super-resolution microscopy to study the organization and function of protein complexes in cells.