Reticular chemistry operates in an infinite space of compositions, structures, properties, and applications. Although great progress has been made in exploring this space through the development of metal-organic frameworks and covalent organic frameworks, there remains a gap between what we foresee as being possible and what can actually be accomplished with the current tools and methods. The establishment of digital reticular chemistry, where digital tools are deployed, in particular laboratory robotics and artificial intelligence, will fundamentally change the current workflow to...